Latisse should be applied every night using only the accompanying sterile applicators. Start by ensuring your face is clean, all makeup is removed, and contact lenses are removed (if applicable). Then carefully place one drop of Latisse solution on the disposable sterile applicator and brush cautiously along the skin of the upper eyelid margin at the base of the eyelashes. If any Latisse solution gets into the eye, it is not expected to cause harm. The eye should not be rinsed. Latisse should not be applied to the lower eyelash line. Any excess solution outside the upper eyelid margin should be blotted with a tissue or other absorbent material.